Armenians in the 17th century in Iran have had significant commercial and economic and cultural and artistic influences during the Safavid period with the cultural interactions that emerged between the Iranian, Armenian and European peoples. Various such paintings are impressive. By examining the paintings of Bethlehem Church it seems that these works must follow the particular style prevailing in religious imagery, and since Christianity paintings have been used to convey the text message from the signs of the Bible, it is necessary to examine the paintings on the basis of analysis. Symbolic, by comparing the symbols in a number of selected works of the Church of Bethlehem and the paintings of the Safavid era and its European counterpart, we find that sometimes the subject of religion is an auxiliary to painting, in addition to drawing on the values governing their intellectual and religious culture of the age. , Thoughts, Worldview and more They also incorporate their ideas into the works by means of symbolism, which in addition to the subject matter is also influenced by the content of the work, and the artist issues symbols in his community using the symbols used in a rhetorical context